Little MA, Nightingale P, Verburgh CA, Hauser T, De Groot K, Savage C et al (2010) Early mortality in systemic vasculitis : relative contribution of adverse events and active vasculitis. Kitching AR, Anders HJ, Basu N, Brouwer E, Gordon J, Jayne DR, Kullman J, Lyons PA, Merkel PA, Savage COS, Specks U, Kain R (2020) ANCA-associated vasculitis. Parikh SV, Rovin BH (2016) Current and emerging therapies for lupus nephritis. Pulmonary involvement and high-dose corticosteroid regimen were the most significant risk factors for infections. Infections occur frequently with current IS regimens in aggressive glomerulonephritis. Pulmonary involvement increased the risk for pulmonary infections (HR 3.67 95% CI, 1.32–10.1) and severe infections (HR 2.45 95% CI, 1.01–5.92). In multivariate Cox regression analysis, high-dose oral corticosteroids (≥ 0.5 mg/kg/day in the first month of induction therapy) was an independent predictor of any infection (HR 2.66 95% CI, 1.5–4.73), severe infections (HR 2.45 95% CI, 1.03–5.82), and pulmonary infections (HR 2.91 95% CI, 1.05–8.01). Most patients developed infections early during the initial induction therapy (62.1% in the first 6 months of follow-up). Patients with AAV had more infections than those with CryoVasc and LN (100.6, 47.5, and 26.6 infections per 100-patient-years, respectively p = 0.002). The incidence rates of infections and severe infections were 38.2 and 14.3 events per 100 patient-years. Eighty-two patients (50.6%) had at least one infection. ResultsĪ total of 179 infection episodes occurred during a follow-up of 468 patient-years. Multivariate Cox proportional hazard regression analysis was performed to identify independent risk factors for infections. Infection incidence, type, site, and grade (1–5) were recorded. MethodsĪ total of 162 patients with aggressive glomerulonephritis were retrospectively reviewed for any infection occurrence. We sought to investigate the infection profile and associated risk factors in a compiled cohort of patients with autoimmune disorders with severe renal involvement treated with aggressive immunosuppressive (IS) regimens.
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